Rendering Biomolecular Coordinates...
KRAS(G12C) : Sotorasib
PDB: 6OIM
Covalent Switch-II pocket inhibitor AMG 510 irreversibly conjugated to mutant Cys12 in the inactive GDP-bound state.
Sotorasib (6OIM)
Adagrasib (6V9F)
Cys12 Site
Switch-II Pocket
Surface
Spin
Reset
Cys12 Nucleophile
Switch-II Loop (59–72)
Covalent Inhibitor